Redefining Cancer Precision Therapy with Next-generation Nano-medicines.

Mission

NovaCode Bio is dedicated to conquering high-impact diseases and addressing critical unmet medical needs.

Strategy

We are harnessing a disruptive platform to target well-established disease pathways - delivering transformative solutions that change lives.

Our Platforms

Driving innovation with state-of-the-art platforms designed to unlock novel therapeutics and ensure targeted delivery.

Two Precision Nano Delivery Platforms

Tumor-targeting nanocarriers engineered for controlled, on-demand therapeutic delivery with enhanced efficacy and minimized toxicity.

Nano‑Carrier-based Peptide-Drug Conjugates (NC-PDC)

NC-PDC Illustration

Modular precision nanomedicine systems integrating:

  • Targeting Peptide or Nanobody Ligands - bind tumor-specific antigens to guide the nanoparticle to target
  • Biocompatible Nanocarrier - protects drug, increases half-life over free drug
  • Covalently loaded payload - prevents premature release of cytotoxic drug
  • Tunable Linkers - controlled, environment-triggered drug release, tuned to tumor microenvironment (TME)

Engineered‑Carrier-based Nanobody-Drug Conjugates (EC-NDC)

EC-NDC Illustration

Result = Potent, safer, versatile, targeted cancer therapy

How they work

The nanocarrier system combines:

  • EPR* accumulation mechanisms
  • Build-in mechanisms:
    • • Active transportation to TME*
    • • Retention in tumor sites
    • • Active targeting - ligands identify tumor cells
    • → enhances accumulation and residence time in tumor tissues
  • Covalent linker prevents premature payload release
  • Tumor microenvironment triggers intracellular drug release
* Enhanced Permeability and Retention * Tumor Microenvironment
How they work

Why they will be superior to ADCs

Greater tumor but not organ exposure

Stable in blood; controlled drug release in tumor

Reduced systemic toxicity

High loading capacity for payloads

Multiple payloads

Scalable solid-phase and solution-phase synthesis

Ease of commercial manufacturing

Platform = multiple oncology indications

Oncology Indications

The NovaCode Advantage

Our unique strengths position us at the forefront of therapeutic innovation.

Pioneering Platforms

Innovative discovery and delivery systems.

Decades of Expertise

35+ years of continuous scientific innovation.

Targeted Solutions

Addressing unreachable disease drivers effectively.

Collaborative Approach

Partnering to accelerate medical breakthroughs.

Our Team

A world-class team with decades of experience in drug discovery, development, and delivery.

KS Lam, MD, PhD

KS Lam, MD, PhD

University of California Davis, California

  • Distinguished Professor, Department of Biochemistry & Molecular Medicine
  • Inventor, OBOC combinatorial chemistry
  • 30 years of clinical experience to treat cancer patients
  • Leader in nanomedicine, drug development and combinatorial chemistry research
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Shawn Mu, MBA, PhD

Shawn Mu, MBA, PhD

  • Co-founder of 2 start-up companies in new drug development, including advanced drug delivery platforms and first-in-class small molecules
  • Extensive experience in drug delivery and the generic drug industry, holding multiple patents in drug delivery technology
  • Management experience at international pharma corporations such as Sanofi-Aventis and KV Pharma
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Stephen Mason, PhD

Stephen Mason, PhD

  • Twenty-five years of drug discovery and development experience on first-in-class small and large molecules
  • Contributed to the discovery of nirmatrelvir, the anti-COVID-19 component of PAXLOVID
  • Experience in both biotech and large pharma, such as Boehringer Ingelheim, Bristol-Myers Squibb, Pfizer, and J&J
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Ruiwu Liu, PhD

Ruiwu Liu, PhD

Professional Researcher at UC Davis Cancer Center; Ph.D. in Medicinal Chemistry;

  • Leader of OBOC/OB2C combinatorial library methods for drug discovery,
  • 100+ peer-reviewed articles (Nature Communications, JACS), 40+ on combinatorial chemistry,
  • 6 patents, and 8 book chapters.
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Focus on Innovation & Exploration

Innovation is at the heart of everything we do. Our journey of discovery is just beginning.